Welcome to the lab of Assistant Professor Tan Yong Zi at the Department of Biological Sciences, National University of Singapore
We use cryogenic electron microscopy (cryo-EM) to understand the structure and function of membrane proteins important in human diseases. We also develop cryo-EM methods to help us solve our biological research problems.
NUS University Town
View of the Science department buildings from the university field
Our office and lab space at the Lee Wee Kheng Building (S1A)
Yong Zi standing next to our Titan Krios with energy filtered K3
Our expert facility manager Shi Jian inspecting the Titan Krios
Our lab at the Second Singapore Structural Biology Symposium
Featured Publications
Tan, Y.Z., Baldwin, P.R., Davis, J.H., Williamson, J.R., Potter, C.S., Carragher, B. and Lyumkis, D., 2017. Addressing preferred specimen orientation in single-particle cryo-EM through tilting. Nature methods, 14(8), p.793.
Kim, J.*, Tan, Y.Z.*, Wicht, K.J., Erramilli, S.K., Dhingra, S.K., Okombo, J., Vendome, J., Hagenah, L.M., Giacometti, S.I., Warren, A.L., Nosol, K., Roepe, P.D., Potter, C.S., Carragher, B., Kossiakoff, A.A., Quick, M., Fidock, D.A. and Mancia, F., 2019. Structure and drug resistance of the plasmodium falciparum transporter pfcrt. Nature, 576(7786), pp.315-320. *Equal contribution
Tan, Y.Z., Zhang, L., Rodrigues, J., Zheng, R.B., Giacometti, S.I., Rosário, A.L., Kloss, B., Dandey, V.P., Wei, H., Brunton, R., Raczkowski, A.M., Athayde, D., Catalão, M.J., Pimentel, M., Clarke, O.B., Lowary, T.L., Archer, M., Niederweis, M., Potter, C.S., Carragher, B. and Mancia, F., 2020. Cryo-EM Structures and Regulation of Arabinofuranosyltransferase AftD from Mycobacteria. Molecular Cell, 78(4), pp.683-699.